pentobarbital will reduce the level or result of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
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pentobarbital will minimize the level or result of tramadol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Lessened AUC of tramadol as well as active metabolite (O-desmethyltramadol) when coadministered with solid CYP3A4 and CYP2B6 inducers
pentobarbital will minimize the level or result of buprenorphine, extensive-performing injection by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Patients who transfer to buprenorphine long-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers should be monitored to be sure buprenorphine plasma degrees are adequate.
pentobarbital will reduce the extent or impact of darunavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will reduce the extent or impact of ixabepilone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will reduce the extent or outcome of fosamprenavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
There are no knowledge on pregnancy exposures in primates similar to intervals prior to the third trimester in human beings.
pentobarbital will lessen the extent or effect of diazepam buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Sturdy or average CYP3A4 inducers may perhaps enhance level of diazepam elimination; therefore, efficacy of diazepam might be lowered.
pentobarbital will reduce the extent or impact of amlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
Barbiturates are metabolized mostly through the hepatic microsomal enzyme method, and the metabolic products and solutions are excreted in the urine, and fewer usually, from the feces. About 25 to fifty per cent of a dose of aprobarbital or phenobarbital is eliminated unchanged during the urine, whereas the amount of other barbiturates excreted unchanged inside the urine get more info is negligible.
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pentobarbital will reduce the extent or effect of elbasvir/grazoprevir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic effect of elbasvir/grazoprevir could possibly be reduced if coadministered with powerful CYP3A inducers and is also consequently contraindicated.
pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can decrease panobinostat amounts by ~70% and bring about remedy failure.